Thyroid Minimally Invasive Carcinoma
Case
1 Young female. Solitary
nodule in left lobe of thyroid, FNA THY4 (equivalent to Bethesda FNA Class V) with cytology suggestive of a
possible papillary carcinoma, left thyroid lobectomy. This is a
Minimally Invasive Follicular Variant of Papillary Carcinoma
(FVPC) comprising a well circumscribed follicular nodule with
a thick fibrous capsule. There is
one prominent focus of capsular invasion with associated vascular invasion. The nuclei are
optically clear with nuclear features of papillary carcinoma indicating follicular variant of papillary
carcinoma with microinvasion, the differential diagnosis being follicular carcinoma with micro-invasion, or
follicular adenoma.
Case 2 Child
with PTEN mutation, right thyroid lobectomy. This is a
Minimally Invasive Follicular
Carcinoma in a child with PTEN mutation. showing foci
of capsular and vascular invasion within the capsule. The phosphatidyl inositol 3-kinase PI3P/AKT kinase
pathway is negatively regulated by PTEN, so mutations in PTEN are associated with thyroid malignancy,
Reference
Hou P, Ji M, Xing M. Association of PTEN gene methylation with genetic alterations in the phosphatidylinositol 3 kinase/AKT signaling
pathway in thyroid tumors. Cancer 2008;113:2440
|